Investigating how a specific receptor affects tooth repair processes
Role of complement receptor C5L2 in reparative dentinogenesis
This study is looking at how a specific receptor in our body helps repair teeth damaged by cavities, and it aims to find new ways to improve treatments for dental issues that affect many people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11042184 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the complement receptor C5L2 in the formation of reparative dentin, which is crucial for repairing teeth affected by dental caries. The study examines how inflammation and the complement system influence the differentiation of dental pulp stem cells (DPSCs) into odontoblasts, the cells responsible for forming dentin. By exploring these cellular and molecular mechanisms, the research aims to identify potential therapeutic targets for enhancing tooth repair and regeneration. Patients may benefit from insights that could lead to improved treatments for dental caries and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing dental caries or related dental issues.
Not a fit: Patients with no dental caries or those who have already undergone extensive dental restoration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance tooth repair and regeneration, improving dental health outcomes.
How similar studies have performed: While the role of the complement system in inflammation is well-established, the specific investigation of C5L2 in tissue regeneration is novel and has not been extensively studied.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Chung, Seung — University of Illinois at Chicago
- Study coordinator: Chung, Seung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.