Investigating how a specific receptor affects tau protein spread in Alzheimer's disease
Targeting emerging P2RX7 signaling pathways in animal models of Alzheimer's disease
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-10809038
This study is looking at how a specific receptor in the brain affects the spread of tau protein, which is connected to Alzheimer's disease, and it aims to find out if blocking this receptor can help slow down the disease by reducing tau buildup.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10809038 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a receptor called P2RX7 influences the spread of tau protein, which is linked to Alzheimer's disease. By studying animal models, the researchers aim to uncover the role of extracellular vesicles in transferring tau between brain cells. They will use a specific inhibitor to see if blocking P2RX7 can reduce tau aggregation, potentially leading to new therapeutic strategies for Alzheimer's. The findings could provide insights into the molecular mechanisms behind tau pathology and its propagation in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Other research has shown promising results in targeting tau pathology, suggesting that this approach could be a valuable addition to existing strategies.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IKEZU, TSUNEYA — MAYO CLINIC JACKSONVILLE
- Study coordinator: IKEZU, TSUNEYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome