Investigating how a specific receptor affects sleep patterns and depression treatment.
Role of the metabotropic glutamate receptor subtype 5 in circadian rhythmmisalignment and depression: Implications for treatment
This study is looking at how a brain receptor affects sleep and mood in people with depression, and it hopes to find better ways to help those who have trouble sleeping and feel down by using special treatments that can help reset their body clocks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10677531 on NIH RePORTER |
What this research studies
This research explores the connection between a receptor in the brain, known as mGluR5, and its role in regulating sleep patterns and mood, particularly in individuals with Major Depressive Disorder (MDD). The study aims to understand how disruptions in circadian rhythms may contribute to depression and how treatments that target these rhythms, called chronobiotics, can be more effectively utilized. By identifying patients who may benefit from these treatments, the research seeks to improve outcomes for those struggling with depression and sleep issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Major Depressive Disorder who also experience sleep disturbances.
Not a fit: Patients without Major Depressive Disorder or those who do not experience circadian rhythm disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for depression by targeting sleep and circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in using chronobiotic treatments for mood disorders, suggesting that this approach may be effective.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Delorenzo, Christine — State University New York Stony Brook
- Study coordinator: Delorenzo, Christine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.