Investigating how a specific receptor affects prostate cancer progression
Integrin-mediated mechanisms of prostate cancer progression
['FUNDING_R01'] · THOMAS JEFFERSON UNIVERSITY · NIH-10440435
This study is looking at a specific protein called αvβ6 that may help prostate cancer grow and spread, especially when it stops responding to usual treatments, to find new ways to treat the disease better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | THOMAS JEFFERSON UNIVERSITY (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10440435 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the αvβ6 integrin receptor in the progression of prostate cancer, particularly in cases that become resistant to standard treatments like chemical castration. The study examines how this receptor influences cancer cell behavior and the surrounding microenvironment, using advanced techniques such as Western blotting and in vitro experiments. By exploring the mechanisms through which αvβ6 promotes cancer cell survival and metastasis, the research aims to identify new therapeutic targets for more effective prostate cancer treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are men diagnosed with prostate cancer, particularly those who have developed resistance to chemical castration treatments.
Not a fit: Patients with early-stage prostate cancer who have not undergone any form of treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that specifically target the mechanisms of prostate cancer progression, potentially improving outcomes for patients.
How similar studies have performed: Previous research has shown promising results in targeting integrins for cancer treatment, suggesting that this approach may lead to significant advancements in prostate cancer therapy.
Where this research is happening
PHILADELPHIA, UNITED STATES
- THOMAS JEFFERSON UNIVERSITY — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LANGUINO, LUCIA R. — THOMAS JEFFERSON UNIVERSITY
- Study coordinator: LANGUINO, LUCIA R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer