Investigating how a specific receptor affects pain in facial nerves
Official title: Resolvin receptor signaling in trigeminal sensory neurons
Funded at Duke University · NIH-10861855 · Data updated 2026-11-12
This study is looking at how a special molecule called resolvin E1 and its receptor might help reduce chronic facial pain, especially for people with conditions like TMJ disorder, to find new ways to relieve pain.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 15, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $161,000 |
| NIH project number | 5R03DE032394-02 |
| Project ID | NIH-10861855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory pain related to temporomandibular joint disorders or other facial pain conditions.
✕Less likely to help
Patients with acute pain not related to chronic inflammatory conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of resolvin E1 and its receptor ChemR23 in managing chronic inflammatory pain, particularly in conditions like temporomandibular joint disorder (TMJD). The study will explore how these molecules interact within the trigeminal nervous system, which is crucial for facial sensation and pain. By measuring levels of resolvin E1 and assessing receptor activity in animal models, the researchers aim to uncover new pathways for pain relief. This could lead to innovative treatments for patients suffering from chronic facial pain.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for chronic facial pain, improving the quality of life for many patients.
How similar studies have gone: Previous studies have shown promise in using lipid mediators like resolvin E1 for pain management, suggesting that this approach could be effective.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Bang, Sangsu — Duke University
- Study coordinator: Bang, Sangsu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.