Investigating how a specific receptor affects pain in facial nerves
Resolvin receptor signaling in trigeminal sensory neurons
['FUNDING_R03'] · DUKE UNIVERSITY · NIH-10861855
This study is looking at how a special molecule called resolvin E1 and its receptor might help reduce chronic facial pain, especially for people with conditions like TMJ disorder, to find new ways to relieve pain.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10861855 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of resolvin E1 and its receptor ChemR23 in managing chronic inflammatory pain, particularly in conditions like temporomandibular joint disorder (TMJD). The study will explore how these molecules interact within the trigeminal nervous system, which is crucial for facial sensation and pain. By measuring levels of resolvin E1 and assessing receptor activity in animal models, the researchers aim to uncover new pathways for pain relief. This could lead to innovative treatments for patients suffering from chronic facial pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory pain related to temporomandibular joint disorders or other facial pain conditions.
Not a fit: Patients with acute pain not related to chronic inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments for chronic facial pain, improving the quality of life for many patients.
How similar studies have performed: Previous studies have shown promise in using lipid mediators like resolvin E1 for pain management, suggesting that this approach could be effective.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BANG, SANGSU — DUKE UNIVERSITY
- Study coordinator: BANG, SANGSU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.