Investigating how a specific receptor affects nerve cell death in aging-related diseases.
Official title: The Role of the p75 Neurotrophin Receptor in Dopaminergic Neurodegeneration Induced by Oxidative Stress.
Funded at University of Alabama in Huntsville · NIH-10437963 · Data updated 2026-11-12
This study is looking at how a specific receptor in the brain might cause the death of important dopamine-producing cells, which is a big concern for people with Parkinson's disease, and it hopes to find new ways to protect these cells and improve treatment options for older adults.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama in Huntsville NIH-funded |
| Lab location | 1 site (Huntsville, United States) |
| Project start | September 15, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2022 |
| Award (this year) | $437,997 |
| NIH project number | 1R15NS111413-01A1 |
| Project ID | NIH-10437963 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of neurodegenerative diseases, particularly those related to dopamine dysfunction.
✕Less likely to help
Patients who are not elderly or do not have neurodegenerative conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the p75 neurotrophin receptor in the death of dopamine-producing neurons, particularly in the context of neurodegenerative diseases like Parkinson's. The researchers will use cultured cells and animal models to explore how oxidative stress activates this receptor and leads to neuronal death. By uncovering the mechanisms involved, the study aims to identify potential new treatment strategies that could prevent or reduce neurodegeneration in older adults.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that slow down or prevent the progression of neurodegenerative diseases in the elderly.
How similar studies have gone: Previous research has shown promise in targeting neurotrophin receptors for neuroprotection, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Alabama in Huntsville
Huntsville, United States Active
Researchers
- Principal investigator: Kraemer, Bradley R — University of Alabama in Huntsville
- Study coordinator: Kraemer, Bradley R
Related research
Other NIH-funded projects on the same topics.
-
How vitamin B12 helps the gum-disease bacterium survive
Learning how vitamin B12 helps the bacteria that cause gum disease survive and become more harmful for people with periodontitis.
-
Pancreatic beta cells, oxidative stress, and gestational diabetes
A study is exploring how oxidative stress and changes in pancreatic beta cells during pregnancy may contribute to gestational diabetes and future diabetes risk for both mother and baby.
-
Environmental air pollutants linked to preeclampsia risk in pregnancy
This study looks at whether common air pollutants called PAHs increase the risk of preeclampsia during pregnancy.
-
Oxidative stress and Nlrp3 inflammasome activation in eye lens aging
This grant looks at how aging and oxidative stress drive inflammation in the eye lens, which could help prevent age-related eye diseases.
-
Glyphosate exposure and young adults' metabolic health
A study will look at how glyphosate exposure relates to metabolism and liver health in young adults, using urine measurements and health data.
-
Protein translation control in heart failure under oxidative stress
This project looks at how heart cells manage oxidative stress and how a protein called Nrf2 is produced, which could reveal new ways to help people with heart failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.