Investigating how a specific receptor affects nerve cell death in aging-related diseases.
The Role of the p75 Neurotrophin Receptor in Dopaminergic Neurodegeneration Induced by Oxidative Stress.
['FUNDING_R15'] · UNIVERSITY OF ALABAMA IN HUNTSVILLE · NIH-10437963
This study is looking at how a specific receptor in the brain might cause the death of important dopamine-producing cells, which is a big concern for people with Parkinson's disease, and it hopes to find new ways to protect these cells and improve treatment options for older adults.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA IN HUNTSVILLE (nih funded) |
| Locations | 1 site (HUNTSVILLE, UNITED STATES) |
| Trial ID | NIH-10437963 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the p75 neurotrophin receptor in the death of dopamine-producing neurons, particularly in the context of neurodegenerative diseases like Parkinson's. The researchers will use cultured cells and animal models to explore how oxidative stress activates this receptor and leads to neuronal death. By uncovering the mechanisms involved, the study aims to identify potential new treatment strategies that could prevent or reduce neurodegeneration in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing symptoms of neurodegenerative diseases, particularly those related to dopamine dysfunction.
Not a fit: Patients who are not elderly or do not have neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that slow down or prevent the progression of neurodegenerative diseases in the elderly.
How similar studies have performed: Previous research has shown promise in targeting neurotrophin receptors for neuroprotection, suggesting potential for success in this novel approach.
Where this research is happening
HUNTSVILLE, UNITED STATES
- UNIVERSITY OF ALABAMA IN HUNTSVILLE — HUNTSVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KRAEMER, BRADLEY R — UNIVERSITY OF ALABAMA IN HUNTSVILLE
- Study coordinator: KRAEMER, BRADLEY R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.