Investigating how a specific receptor affects liver fat metabolism and disease
The Role of ERRa in liver lipid dysfunction and pathology
This study is looking at a new medicine that can help reduce fat buildup in the liver and improve liver health for people with conditions like non-alcoholic fatty liver disease and alcoholic liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10983788 on NIH RePORTER |
What this research studies
This research focuses on the estrogen-related receptor (ERR) and its role in regulating genes that control fat metabolism in the liver. The team has developed a new small molecule inhibitor, ERR-PA, which blocks ERR's action and has shown promise in preventing and reversing liver fat accumulation in models of liver disease. By using both dietary and genetic models, the research aims to uncover how inhibiting ERR can reduce liver inflammation and fibrosis associated with conditions like non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). This could lead to new treatment strategies for patients suffering from liver disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver diseases such as non-alcoholic fatty liver disease (NAFLD) or alcoholic liver disease (ALD).
Not a fit: Patients with liver diseases not related to fat metabolism or those without liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively treat or prevent liver diseases related to fat metabolism.
How similar studies have performed: Other research has shown that targeting metabolic pathways in the liver can lead to significant improvements in liver health, suggesting this approach has potential.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Stiles, Bangyan — University of Southern California
- Study coordinator: Stiles, Bangyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.