Investigating how a specific receptor affects liver and heart damage from alcohol.
Official title: The Role of TP-R on Alcohol-Induced Multi-Organ Damage: Liver and Heart
Funded at University of Nebraska Medical Center · NIH-11014457 · Data updated 2026-11-12
This study is looking at how drinking alcohol affects your liver and heart, especially if you're dealing with obesity, to find out how these factors can harm your organs and help us discover better ways to prevent and treat alcohol-related health problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | February 28, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $241,763 |
| NIH project number | 5P50AA030407-03 |
| Project ID | NIH-11014457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who consume alcohol regularly and may also be dealing with obesity or related health issues.
✕Less likely to help
Patients who do not consume alcohol or have no history of liver or heart disease may not benefit from this research.
What this research studies
This research focuses on understanding the impact of alcohol consumption on liver and heart health, particularly how obesity may worsen these effects. The study examines the role of the thromboxane-prostanoid receptor (TP-R) in mediating liver and cardiac injuries associated with alcohol use. By using animal models, researchers aim to uncover the mechanisms by which alcohol and obesity contribute to organ damage, potentially leading to new therapeutic targets for prevention and treatment. Patients may benefit from insights gained into how to better manage or prevent alcohol-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating liver and heart diseases related to alcohol consumption.
How similar studies have gone: Previous research has shown promising results in understanding the role of specific receptors in alcohol-related diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Viswanathan, Saraswathi — University of Nebraska Medical Center
- Study coordinator: Viswanathan, Saraswathi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.