Investigating how a specific receptor affects intestinal health and cancer development
Role of the complement C3a receptor on immune and non immune intestinal barrier functions and microbiota in colorectal cancer development
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10895338
This study is looking at how a specific receptor in the intestines might help protect against colorectal cancer, especially in its early stages, and it's for anyone interested in understanding how inflammation and immune cell communication could play a role in cancer development.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10895338 on ClinicalTrials.gov |
What this research studies
This research explores the role of the complement C3a receptor in the intestines and its impact on colorectal cancer (CRC) development. It examines how inflammation and the communication between immune and epithelial cells in the intestinal barrier may contribute to CRC initiation. By using genetically modified mice, the study aims to understand the protective effects of the C3a receptor against CRC, particularly in early tumor stages. The research utilizes publicly available data to identify changes in the receptor's expression in CRC patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of colorectal cancer or those diagnosed with early-stage colorectal cancer.
Not a fit: Patients with advanced colorectal cancer or those without any genetic predisposition to CRC may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating colorectal cancer by targeting inflammatory pathways.
How similar studies have performed: Previous studies have indicated that targeting inflammation can prevent CRC, suggesting that this approach may yield significant insights.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GUGLIETTA, SILVIA — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: GUGLIETTA, SILVIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.