Investigating how a specific receptor affects inflammation in the brain after a stroke
Official title: Mrgprb2 mediated neuroinflammation after cerebral ischemia
Funded at Johns Hopkins University · NIH-11086733 · Data updated 2026-11-12
This study is looking at how a specific receptor in the brain affects inflammation after a stroke, with the hope of finding new ways to help stroke patients recover better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $199,480 |
| NIH project number | 5K08NS131599-03 |
| Project ID | NIH-11086733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke and are dealing with the aftermath of brain injury.
✕Less likely to help
Patients who have not had a stroke or do not have conditions related to neuroinflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of a receptor called Mrgprb2 in the inflammation that occurs in the brain following a stroke. By studying animal models, the researchers aim to uncover how this receptor influences the activation of immune cells, which can worsen brain injury. The goal is to identify potential therapeutic strategies that could mitigate neuroinflammation and improve recovery outcomes for stroke patients. This work is being conducted at Johns Hopkins University, a leading institution in neurosurgery and neuroscience.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce brain inflammation and improve recovery after a stroke.
How similar studies have gone: Previous research has shown promise in targeting neuroinflammation as a therapeutic approach in stroke recovery, indicating that this line of investigation could be impactful.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Xu, Risheng — Johns Hopkins University
- Study coordinator: Xu, Risheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.