Investigating how a specific receptor affects inflammation and lung injury.
Official title: Nuclear receptor, PPARg in macrophage polarization, hyperinflammatory gene expression and lung injury
Funded at Johns Hopkins University · NIH-11061269 · Data updated 2026-11-12
This study is looking at how a specific protein in our cells helps immune cells called macrophages respond when the lungs are hurt or inflamed, with the goal of finding new ways to treat lung problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $644,093 |
| NIH project number | 5R01HL170426-06 |
| Project ID | NIH-11061269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing acute lung injury or chronic inflammatory lung conditions.
✕Less likely to help
Patients with stable lung conditions or those not experiencing acute inflammation may not benefit from this research.
What this research studies
This research focuses on understanding the role of the nuclear receptor PPARγ in regulating macrophage behavior during lung injury and inflammation. By examining how macrophages respond to injury and the factors that influence their polarization, the study aims to uncover the mechanisms behind hyperinflammatory responses. The research employs advanced techniques to analyze gene expression and epigenomic changes in macrophages, which could lead to new therapeutic strategies for lung-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for acute lung injuries and related inflammatory diseases.
How similar studies have gone: Previous research has shown promising results in understanding macrophage polarization and its implications for inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Nagy, Laszlo — Johns Hopkins University
- Study coordinator: Nagy, Laszlo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.