Investigating how a specific receptor affects immune cells in obesity-related inflammation
The role of GHS-R in macrophage reprogramming during meta-inflammation
['FUNDING_R01'] · TEXAS A&M AGRILIFE RESEARCH · NIH-10431889
This study is looking at how a specific receptor in the body affects immune cells during inflammation caused by obesity, which could help find new ways to treat inflammation and metabolic problems related to being overweight.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS A&M AGRILIFE RESEARCH (nih funded) |
| Locations | 1 site (College Station, UNITED STATES) |
| Trial ID | NIH-10431889 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the growth hormone secretagogue receptor (GHS-R) in regulating immune cells called macrophages during obesity-related inflammation, known as meta-inflammation. By studying genetically modified mice, the researchers aim to uncover how GHS-R influences the balance between pro-inflammatory and anti-inflammatory macrophages. This could lead to new strategies for treating inflammation and metabolic issues associated with obesity. The approach involves detailed analysis of macrophage behavior and signaling pathways in response to dietary changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are obese or overweight and experiencing related metabolic dysfunctions.
Not a fit: Patients who are not overweight or do not have obesity-related metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve metabolic health in individuals affected by obesity.
How similar studies have performed: Previous research has shown promising results in targeting macrophage polarization for treating obesity-related inflammation, suggesting that this approach may be effective.
Where this research is happening
College Station, UNITED STATES
- TEXAS A&M AGRILIFE RESEARCH — College Station, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, YUXIANG — TEXAS A&M AGRILIFE RESEARCH
- Study coordinator: SUN, YUXIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.