Investigating how a specific receptor affects heart function in people with high blood pressure
Official title: Mineralocorticoid receptor, coronary microvascular function, and cardiac efficiency in hypertension
Funded at Brigham and Women's Hospital · NIH-11001139 · Data updated 2026-11-12
This study is looking at how certain receptors in the body affect heart health in people with high blood pressure and thickened heart muscles, and it will help us understand if blocking these receptors can improve heart function and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $698,386 |
| NIH project number | 5R01HL162960-03 |
| Project ID | NIH-11001139 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with hypertension and left ventricular hypertrophy who are currently on ACE inhibitors.
✕Less likely to help
Patients without hypertension or those who do not have left ventricular hypertrophy may not benefit from this research.
What this research studies
This research explores the relationship between mineralocorticoid receptors and heart function in individuals with hypertension and left ventricular hypertrophy. It aims to understand how these receptors influence coronary microvascular function and cardiac efficiency, which are critical for heart health. Participants will be randomly assigned to receive either a treatment that blocks these receptors or a control, allowing researchers to assess the impact on heart function and overall cardiovascular outcomes. The study is designed to fill a significant gap in current treatments for coronary microvascular dysfunction and abnormal cardiac efficiency.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that improve heart function and reduce cardiovascular risks for patients with hypertension.
How similar studies have gone: Previous research has indicated that targeting mineralocorticoid receptors may improve cardiovascular outcomes, suggesting potential success for this approach.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Adler, Gail Kurr — Brigham and Women's Hospital
- Study coordinator: Adler, Gail Kurr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.