Investigating how a specific receptor affects heart disease linked to antipsychotic medications
Official title: Role of PXR in drug-elicited cardiovascular disease
Funded at University of California Riverside · NIH-10984990 · Data updated 2026-11-12
This study is looking at how a specific protein in the body might affect heart health for people who take certain antipsychotic medications for a long time, with the goal of finding safer treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $640,801 |
| NIH project number | 5R01HL167206-03 |
| Project ID | NIH-10984990 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with bipolar disorder, schizophrenia, or major depressive disorder who are prescribed atypical antipsychotics.
✕Less likely to help
Patients not taking antipsychotic medications or those with cardiovascular disease unrelated to medication use may not benefit from this research.
What this research studies
This research focuses on understanding the role of the pregnane X receptor (PXR) in the cardiovascular risks associated with long-term use of atypical antipsychotic medications. It aims to uncover the mechanisms by which these medications can lead to dyslipidemia and increased cardiovascular disease risk. By utilizing advanced mouse models, including those with specific genetic modifications, the study will explore how PXR influences lipid metabolism and atherosclerosis. The findings could provide insights into safer treatment options for patients requiring antipsychotic therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that minimize cardiovascular risks for patients on antipsychotic medications.
How similar studies have gone: Previous research has indicated that understanding the role of PXR in lipid metabolism could lead to significant advancements in managing medication-related cardiovascular risks, suggesting a promising avenue for this investigation.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Zhou, Changcheng — University of California Riverside
- Study coordinator: Zhou, Changcheng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.