Investigating how a specific receptor affects glioblastoma growth and spread.
Mechanisms underlying BAI1/ADGRB1 negative regulation of glioblastoma mesenchymal transition and invasion.
This study is looking at how a specific receptor called BAI1 affects glioblastoma, a tough type of brain tumor, and aims to find new ways to stop the tumor from growing and spreading, which could help improve treatment for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10892932 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the BAI1 receptor in glioblastoma, a highly aggressive brain tumor. Researchers aim to uncover how the loss of this receptor contributes to the tumor's invasive behavior and poor patient outcomes. By studying the mechanisms behind this process, they hope to identify new therapeutic strategies that could inhibit tumor growth and spread. The project involves laboratory experiments and analysis of patient samples to explore the potential of restoring BAI1 expression as a treatment approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma who are seeking new treatment options.
Not a fit: Patients with non-glioblastoma brain tumors or those who are not eligible for experimental therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates for glioblastoma patients.
How similar studies have performed: Previous studies have shown promise in targeting similar pathways in glioblastoma, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Van Meir, Erwin G. — University of Alabama at Birmingham
- Study coordinator: Van Meir, Erwin G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.