Investigating how a specific receptor affects fat metabolism and liver health
Metabolic Reprogramming by Protease-activated Receptor 2
This study is looking at how a specific protein called PAR2 affects liver health and metabolism in people who have issues like fatty liver disease and insulin resistance due to too much sugar and fat in their diets.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10746130 on NIH RePORTER |
What this research studies
This research explores the role of Protease Activated Receptor-2 (PAR2) in metabolic disorders related to excessive sugar and fat intake, such as non-alcoholic fatty liver disease (NAFLD) and insulin resistance. By analyzing liver specimens and clinical data from patients, the study aims to understand how PAR2 influences cholesterol levels and fat metabolism. The researchers will utilize a cross-sectional approach to compare PAR2 expression in patients with varying stages of NAFLD and assess its potential impact on metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with non-alcoholic fatty liver disease or related metabolic conditions.
Not a fit: Patients without metabolic disorders or those not affected by fatty liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating metabolic disorders like obesity and diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the role of PAR2 in metabolic diseases, indicating potential for significant advancements in this area.
Where this research is happening
Boston, United States
- Tufts Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Kuliopulos, Athan — Tufts Medical Center
- Study coordinator: Kuliopulos, Athan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.