Investigating how a specific receptor affects eye damage in diabetes
Official title: Pro/renin receptor-mediated signaling in pathogenesis of diabetic retinopathy
Funded at University of Florida · NIH-10908720 · Data updated 2026-11-12
This study is looking at how a specific receptor in the eye might contribute to diabetic retinopathy, a condition that can cause vision loss for people with diabetes, and it hopes to find new ways to prevent or treat this eye disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $381,250 |
| NIH project number | 5R01EY035413-02 |
| Project ID | NIH-10908720 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing diabetic retinopathy.
✕Less likely to help
Patients without diabetes or those who do not have any risk factors for diabetic retinopathy may not benefit from this research.
What this research studies
This research focuses on understanding the role of the pro/renin receptor in the development of diabetic retinopathy, a complication of diabetes that can lead to blindness. The study examines how dysregulation of the renin-angiotensin system, particularly the effects of Angiotensin II, contributes to inflammation and oxidative stress in the eye. By exploring the mechanisms of this receptor and its interactions with other cellular processes, the research aims to uncover new insights into how diabetic eye disease progresses. Patients may benefit from findings that could lead to new therapeutic strategies for preventing or treating diabetic retinopathy.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce vision loss in patients with diabetic retinopathy.
How similar studies have gone: Previous research has shown promising results in understanding the role of the renin-angiotensin system in various diabetic complications, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Li, Qiuhong — University of Florida
- Study coordinator: Li, Qiuhong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.