Investigating how a specific receptor affects brain cell development in young rats
Official title: p75NTR regulates oligodendrocyte progenitor development in the SubventricularZone of postnatal rats
Funded at Rutgers the State Univ of Nj Newark · NIH-10877528 · Data updated 2026-11-12
This study is looking at how a specific protein affects the growth of important brain cells in young rats, which could help us understand how to support healthy brain development.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers the State Univ of Nj Newark NIH-funded |
| Lab location | 1 site (Newark, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $235,500 |
| NIH project number | 1R21NS137258-01 |
| Project ID | NIH-10877528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with conditions affecting brain development or myelination, particularly those under 21 years of age.
✕Less likely to help
Patients with fully developed brains or those not affected by oligodendrocyte-related conditions may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of the p75 neurotrophin receptor (p75NTR) in the development of oligodendrocyte progenitor cells in the subventricular zone of postnatal rats. By creating a specialized rat model that lacks this receptor, researchers aim to explore how its absence influences the differentiation and maturation of these brain cells. The study will also examine whether this deletion affects the overall pool of progenitor cells, which are crucial for healthy brain development. The findings could provide insights into the mechanisms that regulate brain cell development and myelination.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthy brain development and potentially addressing conditions related to myelin abnormalities.
How similar studies have gone: While the specific approach of targeting p75NTR in oligodendrocyte progenitors is novel, similar studies have shown promise in understanding cell differentiation and brain development.
Where this research is happening
-
Rutgers the State Univ of Nj Newark
Newark, United States Active
Researchers
- Principal investigator: Friedman, Wilma J — Rutgers the State Univ of Nj Newark
- Study coordinator: Friedman, Wilma J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.