Investigating how a specific protein modification affects the formation of elastic fibers in the body.
Regulatory roles of peptidylarginine deimination in elastogenisis
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11058532
This study is looking at how a process called citrullination affects the creation of elastic fibers that help keep our lungs and arteries flexible, which could help us understand conditions like emphysema and arterial aneurysms better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11058532 on ClinicalTrials.gov |
What this research studies
This research explores the role of citrullination, a protein modification, in the formation of elastic fibers that are crucial for the elasticity of organs and tissues like the lungs and arteries. By using molecular, cellular, and biophysical methods, the study aims to understand how citrullination influences the function of fibroblasts and the regulation of elastogenic proteins. The findings could lead to new insights into conditions associated with abnormal elastic fiber formation, such as emphysema and arterial aneurysms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions like emphysema, arterial aneurysms, or other diseases linked to elastic fiber abnormalities.
Not a fit: Patients without any conditions related to elastic fiber dysfunction or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to elastic fiber dysfunction.
How similar studies have performed: Previous research has shown that targeting protein modifications like citrullination can have beneficial effects in various diseases, indicating potential for success in this area.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HO, I-CHENG — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: HO, I-CHENG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.