Investigating how a specific protein modification affects T cell function in cancer treatment
Phosphorylation of TSC2 (S1365) as a novel Regulator of mTORC1 Signaling in T Cells
This study is looking at how a protein called TSC2 affects T cells, which are important for fighting cancer, and how changing a specific part of this protein might help make T cells work better in cancer treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11059253 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called TSC2 in regulating T cell activation and function, particularly in the context of cancer immunotherapy. The study examines how a specific modification of TSC2, known as phosphorylation at site S1365, influences the activity of a signaling pathway called mTORC1 in T cells. By manipulating this phosphorylation, researchers aim to enhance T cell responses against tumors while also considering the implications for memory T cell generation. This could lead to improved strategies for adoptive cell therapies in cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with cancers who may benefit from enhanced T cell therapies.
Not a fit: Patients with conditions unrelated to T cell function or those not undergoing cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer immunotherapies by optimizing T cell responses.
How similar studies have performed: Other research has shown promising results in manipulating T cell signaling pathways for improved cancer treatment outcomes.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Pearce, Erika L — Johns Hopkins University
- Study coordinator: Pearce, Erika L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.