Investigating how a specific protein modification affects heart health in diabetes
Nox4 and Epigenetics in chronically enhanced cardiac protein O-GlcNAcylation
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-10825115
This study is looking at how diabetes can affect heart health, especially a condition called diabetic cardiomyopathy, by exploring how certain changes in genes might lead to heart problems, with the hope of finding new ways to help people with diabetes keep their hearts healthy.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-10825115 on ClinicalTrials.gov |
What this research studies
This research explores the relationship between diabetes and heart disease, particularly focusing on a condition known as diabetic cardiomyopathy. It examines how changes in gene regulation, influenced by a protein modification called O-GlcNAc, contribute to heart problems in diabetic patients. By studying molecular pathways and using advanced techniques like RNA sequencing, the research aims to uncover the underlying mechanisms that lead to heart failure in individuals with diabetes. The goal is to identify potential targets for new treatments that could improve heart health in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are at risk of developing heart disease or have been diagnosed with diabetic cardiomyopathy.
Not a fit: Patients without diabetes or those who do not have any cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart health and reduce the risk of heart failure in diabetic patients.
How similar studies have performed: While the intersection of diabetes and heart disease is a growing field, this specific approach focusing on O-GlcNAc and its epigenetic implications is relatively novel and has not been extensively tested.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHANG, SAMUEL FORMOSA — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: CHANG, SAMUEL FORMOSA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders