Investigating how a specific protein modification affects heart health in diabetes
Official title: Nox4 and Epigenetics in chronically enhanced cardiac protein O-GlcNAcylation
Funded at University of Alabama at Birmingham · NIH-10825115 · Data updated 2026-11-12
This study is looking at how diabetes can affect heart health, especially a condition called diabetic cardiomyopathy, by exploring how certain changes in genes might lead to heart problems, with the hope of finding new ways to help people with diabetes keep their hearts healthy.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 30, 2024 |
| Project end | May 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $42,629 |
| NIH project number | 1F30HL172687-01 |
| Project ID | NIH-10825115 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who are at risk of developing heart disease or have been diagnosed with diabetic cardiomyopathy.
✕Less likely to help
Patients without diabetes or those who do not have any cardiovascular issues may not benefit from this research.
What this research studies
This research explores the relationship between diabetes and heart disease, particularly focusing on a condition known as diabetic cardiomyopathy. It examines how changes in gene regulation, influenced by a protein modification called O-GlcNAc, contribute to heart problems in diabetic patients. By studying molecular pathways and using advanced techniques like RNA sequencing, the research aims to uncover the underlying mechanisms that lead to heart failure in individuals with diabetes. The goal is to identify potential targets for new treatments that could improve heart health in these patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve heart health and reduce the risk of heart failure in diabetic patients.
How similar studies have gone: While the intersection of diabetes and heart disease is a growing field, this specific approach focusing on O-GlcNAc and its epigenetic implications is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Chang, Samuel Formosa — University of Alabama at Birmingham
- Study coordinator: Chang, Samuel Formosa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.