Investigating how a specific protein modification affects DNA repair processes
Official title: Role of Protein N-Myristoylation in Driving DNA Damage Response
Funded at Emory University · NIH-11033515 · Data updated 2026-11-12
This study is looking at how a specific change to proteins, called N-myristoylation, affects the way our cells fix DNA damage, which is important for keeping our genes healthy, and it could help us find better ways to treat diseases like Alzheimer's and cancer.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $125,000 |
| NIH project number | 1K99GM157498-01 |
| Project ID | NIH-11033515 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to genomic instability, such as Alzheimer's disease or certain cancers.
✕Less likely to help
Patients with stable genetic conditions or those not affected by DNA damage-related diseases may not benefit from this research.
What this research studies
This research explores the role of N-myristoylation, a type of protein modification, in the DNA damage response (DDR), which is essential for maintaining the stability of our genetic material. By examining how this modification influences key proteins involved in DNA repair, the study aims to uncover mechanisms that could lead to improved understanding and treatment of diseases linked to genomic instability, such as Alzheimer's disease and various cancers. The research employs advanced techniques like quantitative proteomics to identify and validate the proteins affected by N-myristoylation, providing insights into their roles in DNA repair pathways.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with DNA damage, potentially improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein modifications in DNA repair, indicating that this approach has potential for significant findings.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Luong, Nho Cong — Emory University
- Study coordinator: Luong, Nho Cong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.