Investigating how a specific protein modification affects breast cancer biology
Role of Transcription Factor ADP-ribosylation in Breast Cancer Biology
This study is looking at how a specific protein change called ADP-ribosylation affects different types of breast cancer, with the goal of finding new ways to treat patients more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11056081 on NIH RePORTER |
What this research studies
This research explores the role of ADP-ribosylation, a modification of proteins, in the biology of breast cancer. The team at UT Southwestern Medical Center is using advanced computational methods to analyze different breast cancer subtypes and identify unique transcription factors that influence cancer growth. By understanding how these factors operate within specific subtypes, the research aims to uncover new therapeutic targets that could lead to more effective treatments for patients. The study also examines how variations in ADP-ribosylation across these subtypes may impact treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with specific subtypes of breast cancer, particularly those with BRCA1/2 mutations.
Not a fit: Patients with non-breast cancer diagnoses or those without identifiable breast cancer subtypes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with breast cancer.
How similar studies have performed: Previous research has shown promising results in targeting specific molecular subtypes of breast cancer, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Kraus, William Lee — Ut Southwestern Medical Center
- Study coordinator: Kraus, William Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.