Investigating how a specific protein modification affects brain health in neurodegenerative diseases.
A Chemical Footprinting Approach towards Poly-ADP-Ribosylation-regulated Biomolecular Condensation
This study is looking at how a specific chemical change in proteins might affect brain cells in diseases like Alzheimer's and ALS, with the hope of finding new ways to protect brain health and develop better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10993180 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of poly-ADP-ribosylation, a chemical modification of proteins, in the context of neurodegenerative diseases like Alzheimer's and ALS. The study aims to explore how this modification affects brain cell responses to stress and contributes to the formation of harmful protein aggregates. By examining the mechanisms involved, the researchers hope to identify potential therapeutic targets that could protect brain function. Patients may benefit from insights that could lead to new treatments for these debilitating conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, ALS, or related neurodegenerative disorders.
Not a fit: Patients with neurodegenerative diseases not related to Alzheimer's or ALS may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve brain health and slow the progression of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for neuroprotection in neurodegenerative diseases, indicating potential for success in this approach.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yu, Yonghao — Columbia University Health Sciences
- Study coordinator: Yu, Yonghao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.