Investigating how a specific protein interacts with a key modification in aging and Alzheimer's disease
Targeting acetylated histone H4 by MLL4
This study is looking at how a specific change in a protein related to aging might be linked to Alzheimer's disease, and it hopes to find new ways to help treat age-related conditions by understanding these processes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11115587 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of acetylation of histone H4, particularly the modification known as H4K16ac, in the aging process and its loss in Alzheimer's disease. The study aims to explore how the protein MLL4 interacts with this modification and its implications for gene expression and cellular processes. By examining the molecular mechanisms involved, the research seeks to uncover potential pathways that could be targeted for therapeutic interventions in age-related disorders. Patients may benefit from insights gained into the biological processes underlying Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or diagnosed with Alzheimer's disease.
Not a fit: Patients with non-age-related cognitive impairments or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease and other age-related disorders.
How similar studies have performed: While the specific approach of targeting H4K16ac through MLL4 is novel, similar studies have shown promise in understanding epigenetic mechanisms in neurodegenerative diseases.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Kutateladze, Tatiana G — University of Colorado Denver
- Study coordinator: Kutateladze, Tatiana G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.