Investigating how a specific protein interaction affects brain cell function in neurodegenerative diseases.
Official title: Analysis of C9ORF72-associated poly (GR) interactions on BAF chromatin remodeling complex structure and function
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11052743 · Data updated 2026-11-12
This study is looking at how a harmful protein linked to frontotemporal dementia and ALS interacts with certain brain cell components, hoping to find out how these interactions cause problems in brain function, which could help develop new treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $236,668 |
| NIH project number | 1K01NS136791-01A1 |
| Project ID | NIH-11052743 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with familial forms of frontotemporal dementia or amyotrophic lateral sclerosis, particularly those with the C9ORF72 genetic mutation.
✕Less likely to help
Patients with sporadic forms of FTD or ALS without the C9ORF72 mutation may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between a toxic protein associated with familial forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and a chromatin remodeling complex in brain cells. By analyzing how these interactions alter the structure and function of the BAF complex, the study aims to uncover the underlying mechanisms that lead to neuronal dysfunction and death. The research employs advanced techniques such as mass spectrometry and gene expression analysis to provide insights into chromatin dysregulation in affected neurons. Patients may benefit from a deeper understanding of these diseases, potentially leading to new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from FTD and ALS.
How similar studies have gone: Previous research has shown promising results in understanding the role of protein interactions in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Lopez Gonzalez, Rodrigo — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lopez Gonzalez, Rodrigo
Related research
Other NIH-funded projects on the same topics.
-
Susceptibility-based MRI biomarkers for multiple sclerosis
A short-term study aims to test MRI biomarkers that could help diagnose and predict MS in patients, using advanced imaging techniques.
-
Population genomics in peripartum cardiomyopathy
A gene-focused study to understand why some women develop heart failure around and after pregnancy, with an emphasis on African ancestry.
-
Broad antiviral therapy by targeting a key enzyme in nucleotide synthesis
A plan to block a human enzyme that many viruses need, with the aim of creating a broad-spectrum antiviral treatment for infections like SARS-CoV-2, influenza, and HSV-1.
-
Cellular-level Vascular Oculomics for Monitoring Systemic Vascular Health
A multi-site project using eye imaging and AI to monitor blood vessel health in people, with devices and software developed across four clinical sites.
-
Cellular-level Eye Signals to Track Vascular Health
A multi-site project aims to create and test portable imaging devices and AI tools that can monitor blood vessel health through the eye.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.