Investigating how a specific protein interaction affects brain cell function in neurodegenerative diseases.
Analysis of C9ORF72-associated poly (GR) interactions on BAF chromatin remodeling complex structure and function
['FUNDING_CAREER'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11052743
This study is looking at how a harmful protein linked to frontotemporal dementia and ALS interacts with certain brain cell components, hoping to find out how these interactions cause problems in brain function, which could help develop new treatments for patients.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11052743 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the interactions between a toxic protein associated with familial forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and a chromatin remodeling complex in brain cells. By analyzing how these interactions alter the structure and function of the BAF complex, the study aims to uncover the underlying mechanisms that lead to neuronal dysfunction and death. The research employs advanced techniques such as mass spectrometry and gene expression analysis to provide insights into chromatin dysregulation in affected neurons. Patients may benefit from a deeper understanding of these diseases, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with familial forms of frontotemporal dementia or amyotrophic lateral sclerosis, particularly those with the C9ORF72 genetic mutation.
Not a fit: Patients with sporadic forms of FTD or ALS without the C9ORF72 mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from FTD and ALS.
How similar studies have performed: Previous research has shown promising results in understanding the role of protein interactions in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOPEZ GONZALEZ, RODRIGO — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: LOPEZ GONZALEZ, RODRIGO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease