Investigating how a specific protein influences obesity variation
A Trim28-ERV axis drives phenotypic variation in obesity
This study is looking at how a protein called Trim28 affects factors that can lead to obesity, helping us understand why some people gain weight differently, and it could provide helpful insights for those struggling with obesity beyond just genetics and lifestyle.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10909000 on NIH RePORTER |
What this research studies
This research explores the role of the Trim28 protein in regulating non-genetic factors that contribute to obesity. By studying animal models, the researchers aim to understand how variations in the expression of certain genes, influenced by Trim28, can lead to different obesity phenotypes. The study focuses on the interaction between Trim28 and endogenous retroviruses, which may affect gene expression and metabolic outcomes. Patients may benefit from insights into the biological mechanisms behind obesity that are not solely based on genetics or environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing unexplained variations in obesity that cannot be attributed to genetic or environmental factors.
Not a fit: Patients whose obesity is clearly linked to genetic factors or environmental influences may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for understanding and treating obesity by targeting non-genetic factors.
How similar studies have performed: Other research has shown promising results in understanding the role of epigenetics in obesity, suggesting that this approach could yield valuable insights.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Pospisilik, John Andrew — Van Andel Research Institute
- Study coordinator: Pospisilik, John Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.