Investigating how a specific protein influences neuron development in the brain.
Official title: Studying the Molecular Regulation of MGE Projection Neuron Identity by St18
Funded at Winifred Masterson Burke Med Res Inst · NIH-11324143 · Data updated 2026-11-12
This study is looking at how a specific part of the brain helps create different types of nerve cells, focusing on a factor called St18 that helps shape these cells, which could lead to better understanding and treatments for brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Winifred Masterson Burke Med Res Inst NIH-funded |
| Lab location | 1 site (White Plains, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $447,500 |
| NIH project number | 7R01NS117695-05 |
| Project ID | NIH-11324143 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to neuronal development or function, particularly those affecting the basal ganglia.
✕Less likely to help
Patients with conditions unrelated to neuronal development or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research focuses on understanding how the medial ganglionic eminence (MGE) in the brain produces different types of neurons, particularly projection neurons that play a crucial role in brain function. The study examines the role of a transcription factor called St18 in guiding the identity of these neurons. By using advanced techniques like gene expression analysis and cell transplantation, researchers aim to uncover the mechanisms that differentiate between types of neurons produced by the MGE. This could provide insights into brain development and potential therapeutic targets for neurological conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurological disorders by enhancing our understanding of neuron development.
How similar studies have gone: Previous research has shown success in understanding neuronal identity through similar molecular approaches, indicating a promising avenue for this study.
Where this research is happening
-
Winifred Masterson Burke Med Res Inst
White Plains, United States Active
Researchers
- Principal investigator: Au, Edmund — Winifred Masterson Burke Med Res Inst
- Study coordinator: Au, Edmund
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.