Investigating how a specific protein helps protect heart cells from injury during blood flow restoration.
ETS2-dependent control in cardiomyocyte ischemia/reperfusion injury
This study is looking at how a protein called ETS2 helps heart cells stay alive during and after a heart attack, and it hopes to find new ways to protect your heart by improving how heart cells communicate with each other.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10889961 on NIH RePORTER |
What this research studies
This research focuses on understanding how the ETS2 protein influences heart cell survival during events like heart attacks. It examines the role of the ERK1/2 signaling pathway, which is crucial for cell growth and death, in protecting heart cells from damage when blood flow is restored after being blocked. By studying the effects of ETS2 on a protein called Connexin43, which is important for cell communication, the research aims to uncover new strategies to improve heart health and reduce injury during ischemic events.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with coronary artery disease or those at risk of heart attacks.
Not a fit: Patients with non-cardiac related conditions or those who do not have risk factors for ischemic heart injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect heart cells during and after heart attacks, potentially improving recovery and outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling pathways in heart cell protection, indicating that this approach has potential for success.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Hill, Joseph a — Ut Southwestern Medical Center
- Study coordinator: Hill, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.