Investigating how a specific protein helps prevent colon injury and aids in healing
Roles for Adenomatous polyposis coli in colon injury prevention and wound healing
['FUNDING_R01'] · UNIVERSITY OF KANSAS LAWRENCE · NIH-10893362
This study is looking at how a protein called APC helps heal the colon and protect it from damage, especially for people with Ulcerative Colitis, using specially modified mice to find better treatments for this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS LAWRENCE (nih funded) |
| Locations | 1 site (LAWRENCE, UNITED STATES) |
| Trial ID | NIH-10893362 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the Adenomatous Polyposis Coli (APC) protein in preventing colon injuries and promoting wound healing, particularly in patients with Ulcerative Colitis (UC). The study utilizes genetically modified mice to explore how mutations in the APC gene affect the colon's ability to heal and maintain normal function. By examining the cellular responses to colon irritants, the research aims to identify mechanisms that could lead to improved treatments for UC and similar inflammatory bowel diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Ulcerative Colitis or those experiencing chronic colon inflammation.
Not a fit: Patients without Ulcerative Colitis or other inflammatory bowel diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance mucosal healing and reduce inflammation in patients with Ulcerative Colitis.
How similar studies have performed: Previous research has shown promising results in understanding the role of APC in intestinal health, suggesting that this approach could yield significant insights.
Where this research is happening
LAWRENCE, UNITED STATES
- UNIVERSITY OF KANSAS LAWRENCE — LAWRENCE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEUFELD, KRISTI L — UNIVERSITY OF KANSAS LAWRENCE
- Study coordinator: NEUFELD, KRISTI L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.