Investigating how a specific protein helps HIV-1 evade the immune system
ESCRT-Related protein PTPN23 as a cofactor for HIV-1 Vpu
['FUNDING_R21'] · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · NIH-10678902
This study is looking at how a specific protein helps the HIV virus avoid the body's defenses, with the goal of finding new ways to improve treatments for people living with HIV.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VETERANS MEDICAL RESEARCH FDN/SAN DIEGO (nih funded) |
| Locations | 1 site (SAN DIEGO, UNITED STATES) |
| Trial ID | NIH-10678902 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the ESCRT-associated protein PTPN23 in the HIV-1 lifecycle, particularly how it interacts with the viral protein Vpu to facilitate the virus's ability to evade the host's immune responses. By examining the mechanisms through which HIV-1 manipulates host cellular processes, the study aims to identify potential therapeutic targets that could improve treatment options for HIV-1 infection. The approach involves techniques such as transient knockdown of PTPN23 to observe its effects on viral release and immune evasion. Patients may benefit from insights gained that could lead to new strategies for combating HIV-1.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals living with HIV-1 who are seeking new treatment options.
Not a fit: Patients who are not infected with HIV-1 or those who are not responsive to current treatments may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune response against HIV-1.
How similar studies have performed: Other research has shown success in targeting viral accessory proteins to enhance immune responses, suggesting that this approach may yield valuable insights.
Where this research is happening
SAN DIEGO, UNITED STATES
- VETERANS MEDICAL RESEARCH FDN/SAN DIEGO — SAN DIEGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STONEHAM, CHARLOTTE A — VETERANS MEDICAL RESEARCH FDN/SAN DIEGO
- Study coordinator: STONEHAM, CHARLOTTE A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.