Investigating how a specific protein helps deliver zinc to cells during infections
Official title: The role of the ZNG1 metallochaperone in the host response to infection
Funded at Vanderbilt University Medical Center · NIH-10881931 · Data updated 2026-11-12
This study is looking at a protein called ZNG1 that helps move zinc into other proteins important for fighting infections, and it's for anyone interested in how zinc deficiency can affect our immune system and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $539,750 |
| NIH project number | 5R01AI178929-02 |
| Project ID | NIH-10881931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from zinc deficiency, which may include those with malnutrition or certain chronic health conditions.
✕Less likely to help
Patients who have adequate zinc levels or those with conditions unrelated to zinc metabolism may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called ZNG1, which is crucial for transporting zinc into other proteins that help the body respond to infections. Zinc is essential for many cellular functions, and its deficiency can lead to serious health issues, including immune dysfunction and increased susceptibility to infections. The study aims to uncover the molecular mechanisms behind how ZNG1 operates, using various biochemical and physiological experiments to explore its interactions with other proteins. By understanding these processes, the research hopes to shed light on the broader implications of zinc deficiency in human health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving immune function and reducing infection risk in individuals with zinc deficiency.
How similar studies have gone: Previous research has shown promising results in understanding the role of metallochaperones in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Skaar, Eric P — Vanderbilt University Medical Center
- Study coordinator: Skaar, Eric P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.