Investigating how a specific protein helps cancer cells survive stress
Probing a novel signaling complex that sustains AKT activation to support stress survival in cancer
This study is looking at how cancer cells stay alive and keep growing even when they're under stress, like not getting enough nutrients, by focusing on a specific protein that helps them survive tough situations.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10917140 on NIH RePORTER |
What this research studies
This research focuses on understanding how cancer cells manage to survive under stressful conditions, such as lack of nutrients. It examines a protein complex that activates a key signaling pathway (AKT) that is often overactive in cancer. By studying this complex, researchers aim to uncover how cancer cells resist cell death and continue to grow, even when faced with challenges. The approach involves analyzing various cancer cell lines to see how they respond to stress and what role this protein plays in their survival.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with aggressive forms of cancer that exhibit resistance to treatment and survive under nutrient-deprived conditions.
Not a fit: Patients with early-stage or non-aggressive cancers may not receive significant benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target cancer cell survival mechanisms, potentially improving outcomes for patients with aggressive cancers.
How similar studies have performed: Other research has shown promising results in targeting similar signaling pathways in cancer, suggesting that this approach could be effective.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Zanotelli, Matthew R — Cornell University
- Study coordinator: Zanotelli, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.