Investigating how a specific protein fusion affects leukemia treatment outcomes
Official title: Functional and Pharmacologic Investigation of the NUP98 Fusion Oncoprotein Interactome
Funded at St. Jude Children's Research Hospital · NIH-10883772 · Data updated 2026-11-12
This study is looking at a specific protein called NUP98 that is linked to pediatric acute myeloid leukemia (AML) to see how it interacts with other proteins in cells, which could help us find new ways to treat this type of cancer and improve outcomes for kids battling it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $140,959 |
| NIH project number | 5K99CA283256-02 |
| Project ID | NIH-10883772 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients diagnosed with acute myeloid leukemia who have NUP98 gene rearrangements.
✕Less likely to help
Patients with other types of leukemia or those without NUP98 fusions may not benefit from this research.
What this research studies
This research focuses on understanding the role of the NUP98 fusion oncoprotein in pediatric acute myeloid leukemia (AML). It aims to identify the proteins that interact with NUP98 in cellular structures known as puncta, which are crucial for gene regulation and cancer progression. By using advanced techniques, including CRISPR, the study will explore how these interactions influence leukemia cell behavior and resistance to therapy. The ultimate goal is to uncover potential therapeutic targets that could improve treatment outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance survival rates for children with AML associated with NUP98 fusions.
How similar studies have gone: Previous research has shown promising results in targeting similar oncogenic fusions in leukemia, suggesting that this approach could be effective.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Michmerhuizen, Nicole — St. Jude Children's Research Hospital
- Study coordinator: Michmerhuizen, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.