Investigating how a specific protein fusion affects leukemia treatment outcomes
Functional and Pharmacologic Investigation of the NUP98 Fusion Oncoprotein Interactome
This study is looking at a specific protein called NUP98 that is linked to pediatric acute myeloid leukemia (AML) to see how it interacts with other proteins in cells, which could help us find new ways to treat this type of cancer and improve outcomes for kids battling it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10883772 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the NUP98 fusion oncoprotein in pediatric acute myeloid leukemia (AML). It aims to identify the proteins that interact with NUP98 in cellular structures known as puncta, which are crucial for gene regulation and cancer progression. By using advanced techniques, including CRISPR, the study will explore how these interactions influence leukemia cell behavior and resistance to therapy. The ultimate goal is to uncover potential therapeutic targets that could improve treatment outcomes for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients diagnosed with acute myeloid leukemia who have NUP98 gene rearrangements.
Not a fit: Patients with other types of leukemia or those without NUP98 fusions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance survival rates for children with AML associated with NUP98 fusions.
How similar studies have performed: Previous research has shown promising results in targeting similar oncogenic fusions in leukemia, suggesting that this approach could be effective.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Michmerhuizen, Nicole — St. Jude Children's Research Hospital
- Study coordinator: Michmerhuizen, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.