Investigating how a specific protein from bone cells can enhance bone formation
Official title: Bone anabolic effects of osteoclast-produced phospho-Wnt5a
Funded at Emory University · NIH-10929243 · Data updated 2026-11-12
This study is looking at a special protein called Wnt5a that helps bone-building cells work better, with the hope of creating new treatments to strengthen bones for people who have weak bones or are at risk of fractures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $313,000 |
| NIH project number | 1R56AR080718-01A1 |
| Project ID | NIH-10929243 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with osteopenia or conditions that lead to weakened bones.
✕Less likely to help
Patients with healthy bone density or those not experiencing bone-related issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of a phosphorylated protein called Wnt5a, produced by osteoclasts, in promoting bone formation. By studying how this protein interacts with other bone cells, the researchers aim to develop new treatments for conditions that lead to weak bones and fractures. The approach includes both laboratory experiments and potential future applications in patients, with the goal of creating a new anabolic drug that could help strengthen bones. The research will utilize advanced techniques, including the generation of stem cells that express modified versions of Wnt5a to explore its effects on bone health.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve bone health and reduce the risk of fractures in patients with osteopenic conditions.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance bone formation, indicating potential for success in this area.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Drissi, Moulay Hicham — Emory University
- Study coordinator: Drissi, Moulay Hicham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.