Investigating how a specific protein enhances antiviral responses
A new mechanism of antiviral activity of 2-5 Oligoadenylate Synthetase 1
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-11222010
This study is looking at how a protein called OAS1, especially a version called OAS1 P46, helps your body fight off viruses better, which could lead to new ways to boost your immune system against infections.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11222010 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding a new mechanism by which a protein called Oligoadenylate Synthetase 1 (OAS1) enhances the body's antiviral response. The study examines how this protein, particularly a specific isoform known as OAS1 P46, can increase the production of antiviral proteins that help fight off viral infections. By analyzing the genetic variations and alternative splicing of the OAS1 gene, researchers aim to uncover how this protein functions independently of its known enzymatic activity. This could lead to new insights into how the immune system can be harnessed to better combat viral infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variations in the OAS1 gene or those who are at risk for viral infections.
Not a fit: Patients with viral infections that do not involve the mechanisms studied in this research may not benefit from the findings.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the body's ability to fight viral infections.
How similar studies have performed: Previous research has shown promising results in understanding the antiviral mechanisms of similar proteins, suggesting potential for success in this area.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARKAR, SAUMENDRA N — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SARKAR, SAUMENDRA N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.