Investigating how a specific protein contributes to cancer and finding ways to target it with drugs
Dissection of EWS-FLI1 oncogenic mechanisms and small molecule targeting
This study is looking at a protein called EWS-FLI1 that plays a role in Ewing sarcoma, a type of cancer, to see how it works with a part of the cell that helps process RNA, and the goal is to find new small molecules that could block this protein and lead to better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10861010 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the EWS-FLI1 protein in Ewing sarcoma, a type of cancer. It explores how this protein interacts with the spliceosome, a complex involved in RNA processing, and how these interactions may lead to cancer development. The researchers aim to identify small molecules that can inhibit the function of EWS-FLI1, potentially leading to new treatment options. By using advanced techniques like CRISPR, they will analyze the effects of these interactions on cancer cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Ewing sarcoma or related cancers that involve the EWS-FLI1 protein.
Not a fit: Patients with cancers not associated with the EWS-FLI1 protein or those with advanced disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with Ewing sarcoma.
How similar studies have performed: Previous research has shown promise in targeting similar oncogenic proteins, suggesting potential for success in this approach.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Toretsky, Jeffrey a — Georgetown University
- Study coordinator: Toretsky, Jeffrey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.