Investigating how a specific protein contributes to acute myeloid leukemia.
IDP mediated transcriptional stabilization as a cause of AML
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11065543
This study is looking at a protein called MN1 to see how it might be involved in making acute myeloid leukemia worse, with the hope of finding new treatments for patients who aren't doing well with current options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11065543 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of the Meningioma-1 (MN1) protein in acute myeloid leukemia (AML), which is often linked to poor patient outcomes. The study examines how MN1 interacts with other proteins to stabilize certain genetic elements that may lead to the development of leukemia. By understanding these mechanisms, researchers aim to identify new targeted therapies for patients who are not responding well to existing treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those who have not responded to conventional therapies.
Not a fit: Patients with other types of leukemia or those who are in remission from AML may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with acute myeloid leukemia, improving their treatment options and outcomes.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in leukemia, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERNT, KATHRIN M — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: BERNT, KATHRIN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.