Investigating how a specific protein complex in nerve cells affects pain sensation.
The Role of the Neuronal Membrane Proteasome in the Peripheral Nervous System and Pain Sensation
['FUNDING_FELLOWSHIP'] · JOHNS HOPKINS UNIVERSITY · NIH-11002264
This study is looking at how a special protein complex in our nerve cells affects pain signals in the body, with the hope of finding new ways to help manage pain for people who experience it.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11002264 on ClinicalTrials.gov |
What this research studies
This research explores the role of a specialized protein complex, known as the neuronal membrane proteasome, in regulating pain within the peripheral nervous system. It aims to understand how this complex interacts with nerve cells and influences pain signaling, particularly under different conditions of inhibition. By examining the effects of this proteasome on pain sensitivity and neuronal activity, the study seeks to uncover new therapeutic targets for pain management. Patients may benefit from insights gained about pain mechanisms and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain or conditions related to nerve sensitivity.
Not a fit: Patients with acute pain not related to nerve function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing pain more effectively.
How similar studies have performed: Previous research has shown promising results in understanding the role of proteasomes in pain regulation, indicating that this approach may lead to significant advancements.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHURCH, TAYLOR RENNE — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CHURCH, TAYLOR RENNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.