Investigating how a specific protein complex in nerve cells affects pain sensation.
Official title: The Role of the Neuronal Membrane Proteasome in the Peripheral Nervous System and Pain Sensation
Funded at Johns Hopkins University · NIH-11002264 · Data updated 2026-11-12
This study is looking at how a special protein complex in our nerve cells affects pain signals in the body, with the hope of finding new ways to help manage pain for people who experience it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS134239-02 |
| Project ID | NIH-11002264 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing chronic pain or conditions related to nerve sensitivity.
✕Less likely to help
Patients with acute pain not related to nerve function may not receive benefit from this research.
What this research studies
This research explores the role of a specialized protein complex, known as the neuronal membrane proteasome, in regulating pain within the peripheral nervous system. It aims to understand how this complex interacts with nerve cells and influences pain signaling, particularly under different conditions of inhibition. By examining the effects of this proteasome on pain sensitivity and neuronal activity, the study seeks to uncover new therapeutic targets for pain management. Patients may benefit from insights gained about pain mechanisms and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing pain more effectively.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteasomes in pain regulation, indicating that this approach may lead to significant advancements.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Church, Taylor Renne — Johns Hopkins University
- Study coordinator: Church, Taylor Renne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.