Investigating how a specific protein complex controls embryonic development.
Official title: Role Of Retinoid Oxidoreductase Complex In Controlling The Embryonic Development
Funded at University of Alabama at Birmingham · NIH-11057588 · Data updated 2026-11-12
This study is looking at how two proteins work together to help make a vital vitamin A-related molecule that is important for proper development, which could help us understand more about growth and health issues related to it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $280,665 |
| NIH project number | 5R01GM141546-03 |
| Project ID | NIH-11057588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with developmental disorders potentially related to retinoid metabolism.
✕Less likely to help
Patients with conditions unrelated to vitamin A metabolism or embryonic development may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of a protein complex involved in the synthesis of all-trans-retinoic acid (RA), a crucial molecule derived from vitamin A that regulates gene expression during embryonic development. The study aims to uncover the mechanisms that control the levels of retinaldehyde, a precursor to RA, by examining the interactions between two key proteins, RDH10 and DHRS3. By exploring how these proteins influence RA production, the research seeks to clarify the precise regulation of developmental processes that depend on RA concentration. This could provide insights into developmental biology and potential implications for related health issues.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of developmental disorders linked to vitamin A metabolism.
How similar studies have gone: While the specific mechanisms being investigated may be novel, previous studies have shown the importance of retinoic acid in development, indicating a foundation for potential success.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Beliaeva, Olga V — University of Alabama at Birmingham
- Study coordinator: Beliaeva, Olga V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.