Investigating how a specific protein affects the spread of triple-negative breast cancer.

Who could benefit from this research

What this research studies

This research focuses on understanding the role of a protein called ACKR1 in the spread of triple-negative breast cancer (TNBC), which is known for its aggressive nature and high rates of metastasis. The study aims to explore how ACKR1 interacts with a chemokine called CXCL2 to facilitate the movement of cancer cells from the bloodstream into other tissues. By examining these interactions in a controlled environment, researchers hope to uncover critical mechanisms that drive TNBC metastasis, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about how to prevent or reduce the spread of their cancer.

Why it matters

Where this research is happening

• University of Illinois at Chicago
  Chicago, United States Active

Researchers

• Principal investigator: Roach, Samuel — University of Illinois at Chicago
• Study coordinator: Roach, Samuel

Related research

Other NIH-funded projects on the same topics.

• Stable, ultra-tight peptides to block EphB4 and stop TNBC spread

  A new peptide-based approach aims to block a cancer molecule called EphB4 to prevent metastasis in triple-negative breast cancer, especially in African American women.

  NIH research Texas Southern University · Houston, United States · NIH-11420423

• Understanding how high triglycerides may fuel certain breast cancers

  High triglycerides may help triple negative breast cancer grow and spread, and this study looks at how that could happen in patients and models.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11384586

• Stopping triple-negative breast cancer spread by targeting EYA3 and PP2A

  Researchers are exploring whether blocking the EYA3/PP2A pathway can prevent triple-negative breast cancer from spreading and help the immune system fight the tumor.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11290382

• How low PHGDH changes sugar metabolism to help triple‑negative breast cancer spread

  This project looks at how low levels of the enzyme PHGDH change sialic acid sugar metabolism in ways that help triple‑negative breast cancer cells spread.

  NIH research Michigan State University · East Lansing, United States · NIH-11285392

• Stable, ultra‑high affinity peptides that block EphB4 to stop triple‑negative breast cancer from spreading

  Designer peptides that latch onto the EphB4 protein are being developed to try to stop triple‑negative breast cancer from spreading, with attention to the higher risk seen in African American women.

  NIH research Texas Southern University · Houston, United States · NIH-11234607

• How high triglycerides may help triple negative breast cancer grow and spread

  Researchers are looking at whether high blood triglyceride levels make triple negative breast cancer grow and spread faster, which could point to ways to help women with TNBC.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11171486

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.