Investigating how a specific protein affects the body's response to sepsis
ADAM10 as a molecular specifier of sepsis
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-10865837
This study is looking at how a protein called ADAM10 affects sepsis, a serious condition caused by infections, to help find new ways to improve treatments for patients dealing with this illness.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10865837 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the ADAM10 protein in sepsis, a severe condition caused by the body's extreme response to infection. The study will utilize experimental methods and mouse models to explore how different pathogens interact with ADAM10, leading to harmful effects on blood vessels and overall organ function. By identifying the molecular mechanisms involved, the research aims to uncover new insights that could lead to better treatments for sepsis. Patients may benefit from advancements in therapies that target these pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of developing sepsis, particularly those with infections that could lead to severe complications.
Not a fit: Patients who are not at risk for sepsis or those with conditions unrelated to infectious diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating sepsis, potentially improving survival rates and outcomes for affected patients.
How similar studies have performed: Previous research has shown promise in understanding the role of specific proteins in sepsis, but this approach focusing on ADAM10 is relatively novel.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALFANO, DANIELLE NICOLE — WASHINGTON UNIVERSITY
- Study coordinator: ALFANO, DANIELLE NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Disease Models