Investigating how a specific protein affects pancreatic cancer growth and spread
Official title: The Role of Guanine Exchange Factors in Pancreatic Ductal Adenocarcinoma (PDAC)
Funded at Wayne State University · NIH-11228868 · Data updated 2026-11-12
This study is looking at a protein called RCC1 to see how it affects pancreatic cancer cells, with the hope that understanding its role could help develop new treatments for patients facing this tough disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $3,000 |
| NIH project number | 3F99CA294132-01S1 |
| Project ID | NIH-11228868 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma.
✕Less likely to help
Patients with other types of cancer or those without pancreatic ductal adenocarcinoma may not benefit from this research.
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDAC), a type of cancer known for its poor prognosis and limited treatment options. The study examines the role of a protein called RCC1, which is involved in transporting molecules between the nucleus and cytoplasm of cells. By using advanced techniques to analyze gene expression and metabolism, the researchers aim to understand how RCC1 influences cancer cell behavior and contributes to tumor progression. Patients may benefit from insights that could lead to new therapeutic strategies targeting this protein.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for pancreatic cancer patients by targeting the mechanisms that drive tumor growth.
How similar studies have gone: While the specific role of RCC1 in PDAC is being investigated, similar approaches targeting metabolic pathways in cancer have shown promise in other studies.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Bannoura, Sahar — Wayne State University
- Study coordinator: Bannoura, Sahar
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Investigating how a specific protein affects pancreatic cancer growth
This study is looking at how a protein called RCC1 affects the growth of pancreatic cancer, with the hope that understanding its role could help develop new treatments for patients facing this tough diagnosis.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.