Investigating how a specific protein affects pancreatic cancer growth
Studying the role of eIF4A in Pancreatic Cancer
This study is looking at a tough type of cancer called pancreatic ductal adenocarcinoma and is testing how a protein called eIF4A affects cancer cell growth, with the hope of finding new ways to treat this cancer without harming healthy cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10854904 on NIH RePORTER |
What this research studies
This research focuses on pancreatic ductal adenocarcinoma (PDA), a challenging cancer to treat. The team is exploring the role of a protein called eIF4A, which is crucial for the growth of cancer cells. By using advanced models, including genetically-engineered mice and organoids, they aim to understand how inhibiting eIF4A can selectively disrupt the growth of PDA cells while sparing normal cells. The study will also investigate the specific mRNAs that eIF4A helps translate, which could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma.
Not a fit: Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target pancreatic cancer cells, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting metabolic pathways in cancer cells, indicating potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Chio, Christine Iok in — Columbia University Health Sciences
- Study coordinator: Chio, Christine Iok in
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.