Investigating how a specific protein affects pain regulation
Official title: Role of Primary Sensory Neuron CaMKII Signaling in Regulation of Pain
Funded at University of Texas Med Br Galveston · NIH-11126083 · Data updated 2026-11-12
This study is looking at how a protein called CaMKII affects pain in nerve cells, with the goal of finding new ways to relieve chronic pain without using opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $630,092 |
| NIH project number | 5R01NS128410-03 |
| Project ID | NIH-11126083 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who experience chronic pain and are seeking alternative treatments.
✕Less likely to help
Patients who do not experience chronic pain or are under 21 years old may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called CaMKII in the regulation of pain, particularly in primary sensory neurons. By examining how CaMKII signaling functions in these neurons, the researchers aim to uncover new mechanisms that could lead to non-opioid pain relief strategies. The study utilizes techniques such as dorsal root ganglion field stimulation to explore how this protein can influence pain sensations and potentially provide insights into treating chronic pain without the risks associated with opioid use.
Why it matters
Potential benefit: If successful, this research could lead to new, safer pain management options that do not rely on opioids.
How similar studies have gone: Previous studies have shown promise in exploring similar mechanisms, but this specific focus on CaMKII in sensory neurons is relatively novel.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Pan, Bin — University of Texas Med Br Galveston
- Study coordinator: Pan, Bin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.