Investigating how a specific protein affects neuron vulnerability in Alzheimer's disease
Ectodermal-neural cortex 1 and neuronal vulnerability to tau pathology in Alzheimer's disease
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11014450
This study is looking at how a protein called ENC1 affects brain cells in Alzheimer's disease to find out why some neurons are more likely to get damaged, with the hope of discovering new ways to protect those cells and slow down the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11014450 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding why certain neurons in the brain are more susceptible to damage in Alzheimer's disease (AD). It examines the role of a protein called ectodermal-neural cortex 1 (ENC1) in regulating neuron health and its potential impact on tau pathology, which is a hallmark of AD. By analyzing genetic data from brain cells, the researchers aim to identify how ENC1 levels change in healthy versus diseased brains and how this might influence the progression of Alzheimer's. The goal is to uncover new therapeutic targets that could help protect vulnerable neurons from degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting molecular pathways related to tau pathology, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FU, HONGJUN — OHIO STATE UNIVERSITY
- Study coordinator: FU, HONGJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease brain, Alzheimer's disease pathology