Investigating how a specific protein affects neuron structure and function
Official title: Role of TRIM46 in neuronal polarity in vivo
Funded at Baylor College of Medicine · NIH-10918093 · Data updated 2026-11-12
This study is looking at a protein called TRIM46 to see how it helps shape the parts of nerve cells that receive and send signals, which is important for keeping our brains healthy, and it could help us understand more about brain disorders when things go wrong.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31NS134125-02 |
| Project ID | NIH-10918093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurodevelopmental or neurodegenerative disorders that may be linked to neuronal polarity issues.
✕Less likely to help
Patients with purely psychiatric conditions unrelated to neuronal structure or function may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called TRIM46 in the polarization of neurons, which is crucial for their proper functioning. Neurons have two main parts: dendrites that receive signals and axons that send them out. The study will explore how TRIM46 influences the structure of these parts, particularly how microtubules, which are essential for neuron growth and transport, are organized. By examining these processes in living organisms, the research aims to uncover new insights into how disruptions in neuronal polarity may contribute to neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodevelopmental and neurodegenerative disorders by restoring proper neuronal function.
How similar studies have gone: While the specific focus on TRIM46 and its role in microtubule fasciculation is novel, previous research has shown that understanding neuronal structure can lead to breakthroughs in treating neurological disorders.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Melton, Allison Jacqueline — Baylor College of Medicine
- Study coordinator: Melton, Allison Jacqueline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.