Investigating how a specific protein affects neuron structure and function
Role of TRIM46 in neuronal polarity in vivo
['FUNDING_FELLOWSHIP'] · BAYLOR COLLEGE OF MEDICINE · NIH-10918093
This study is looking at a protein called TRIM46 to see how it helps shape the parts of nerve cells that receive and send signals, which is important for keeping our brains healthy, and it could help us understand more about brain disorders when things go wrong.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10918093 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called TRIM46 in the polarization of neurons, which is crucial for their proper functioning. Neurons have two main parts: dendrites that receive signals and axons that send them out. The study will explore how TRIM46 influences the structure of these parts, particularly how microtubules, which are essential for neuron growth and transport, are organized. By examining these processes in living organisms, the research aims to uncover new insights into how disruptions in neuronal polarity may contribute to neurological disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental or neurodegenerative disorders that may be linked to neuronal polarity issues.
Not a fit: Patients with purely psychiatric conditions unrelated to neuronal structure or function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating neurodevelopmental and neurodegenerative disorders by restoring proper neuronal function.
How similar studies have performed: While the specific focus on TRIM46 and its role in microtubule fasciculation is novel, previous research has shown that understanding neuronal structure can lead to breakthroughs in treating neurological disorders.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MELTON, ALLISON JACQUELINE — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: MELTON, ALLISON JACQUELINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.