Investigating how a specific protein affects muscle stem cells in adults
The role of P16Ink4a in adult skeletal muscle stem cells
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11090359
This study is looking at a protein called P16Ink4a to see how it affects muscle stem cells in adults, helping us understand how these cells move, grow, and decide what type of cells to become, which could be important for improving muscle repair and health as we age or deal with muscle diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11090359 on ClinicalTrials.gov |
What this research studies
This research explores the role of the P16Ink4a protein in adult muscle stem cells, focusing on how it influences cell migration, proliferation, and fate decisions. By utilizing advanced genetic strategies, the researchers aim to uncover the mechanisms by which P16Ink4a regulates the behavior of these stem cells, particularly in non-aged tissues. The study will also examine how P16Ink4a interacts with the cell's environment to impact muscle repair and function, which could have implications for aging and muscle degenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who are experiencing muscle degeneration or related conditions.
Not a fit: Patients with acute muscle injuries or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for muscle degeneration and age-related conditions, improving recovery and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of proteins in stem cell function, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FEELEY, BRIAN — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FEELEY, BRIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.