Investigating how a specific protein affects memory and learning in the brain
Role of PSD-95-linked PDE4A5 in Regulation of AMPA Receptors
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-10928802
This study is looking at how a protein called PDE4A5 helps control another protein that affects memory and learning, especially when people are sleep-deprived, to better understand how our brains work.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-10928802 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a protein called PDE4A5 in regulating AMPA receptors, which are crucial for synaptic plasticity and memory. By examining how PDE4A5 interacts with another protein, PSD-95, the research aims to uncover mechanisms that influence the trafficking of AMPA receptors to the synapse, thereby affecting learning and memory processes. The study employs advanced imaging techniques to visualize these interactions and their effects on brain function, particularly in the context of cognitive deficits caused by conditions like sleep deprivation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing cognitive deficits, particularly those related to memory and learning.
Not a fit: Patients with cognitive impairments not related to AMPA receptor function or those without any cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cognitive deficits associated with brain disorders.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways for cognitive enhancement, indicating potential for success in this approach.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ESTRADA-TOBAR, ZOILA MARIBEL — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: ESTRADA-TOBAR, ZOILA MARIBEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.