Investigating how a specific protein affects lung cell function and repair.
Official title: MYRF as an Entry Point to Study Mesothelium Function in Lung Development and Injury Repair
Funded at University of California, San Diego · NIH-11016948 · Data updated 2026-11-12
This study is looking at how a protein called MYRF helps the cells that line the lungs work, especially after injuries, to find better ways to treat lung problems like congenital diaphragmatic hernia, which could help patients breathe easier and improve their lung health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $513,744 |
| NIH project number | 5R01HL172027-02 |
| Project ID | NIH-11016948 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with congenital diaphragmatic hernia or other lung-related conditions.
✕Less likely to help
Patients with non-lung related conditions or those who do not have any respiratory issues may not benefit from this research.
What this research studies
This research focuses on the mesothelium, a crucial cell layer that lines the lungs and other organs, to understand its role in lung development and repair after injury. The study examines the Myelin Regulatory Factor (MYRF), a protein that may influence how these cells function, especially in conditions like congenital diaphragmatic hernia. By exploring how MYRF affects lung cells, the research aims to uncover new insights into lung health and potential treatments for related conditions. Patients may benefit from improved understanding and therapies for lung injuries and diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for lung injuries and conditions affecting lung function.
How similar studies have gone: Previous research has shown promising results in understanding lung cell functions, but this specific approach focusing on MYRF is relatively novel.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Sun, Xin — University of California, San Diego
- Study coordinator: Sun, Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.